Dengue is a self-limited, systemic viral infection transmitted between humans by mosquitoes. The rapidly expanding dengue is a public health challenge with an economic burden that is currently unmet by licensed vaccines, specific therapeutic agents and efficient vector-control strategies.

Clinical Manifestations of Dengue fever:

After an incubation period of 3 to 7 days, the initial febrile phase is typically characterized by high fever associated with headache, vomiting, myalgias (body aches), and joint pain, sometimes with a transient macular rash. Children have high fever but are usually less symptomatic than adults during this phase of the illness. Other symptoms include mild hemorrhagic manifestations such as petechiae and bruising, particularly at venipuncture sites. Liver is palpable most of the times. This phase lasts for 3 to 7 days, after which most patients recover without complications. Continue reading →